Dr. Pacheco is the Director of the Andrology Laboratory and the Sperm Bank at IVI Madrid, IVI Valladolid and IVI Salamanca. He is also assistant professor of Immunology at Alfonso X “El Sabio” University in Madrid since 2000. He completed his Bachelor’s degree in Biology in 1992, and obtained his Ph.D. in Biological Sciences in 1997, both from the Complutense University, in Madrid. He also received a Masters degree in Reproductive Medicine in 2005.

As a researcher, his areas of interest includ molecular markers of male and female infertility, sperm DNA fragmentation, laboratory QA/QC, peripheral and uterine natural killer (NK) cell characterization in women with recurrent miscarriages and implantation failure. Dr Pacheco has published over 25 original peer review articles in leading reproductive journals, many of these were in Immunology journals. He also contributed several book chapters and made over 80 presentations at national and international scientific meetings.
Dr. Pacheco is the recipient of several grants from public and private organizations in Spain (FIS Projects, CDTI), and serves as reviewer in reproductive journals including Fertility Sterility, RBM online, Asian Journal of Andrology, Journal of Assisted Reproduction and Genetics and Journal of Cellular and Molecular Medicine. He has also served on the executive board of Andrology Special Interest Group in the Spanish Society for Reproductive Biology (ASEBIR).
Dr. Pacheco has been involved in teaching since his early career, and has a number of teaching commitments. He is among the faculty for a number of post graduate/Masters courses in Human Reproduction, provided by Spanish Fertility Society, Rey Juan Carlos University of Madrid, University of Valencia, and Europea University of Madrid. Dr. Pacheco is also the coordinator of Immunology courses for students enrolled in Medicine, Pharmacy and Veterinary degrees at Alfonso X “El Sabio” University of Madrid.

Education

Publications

• High sperm DNA fragmentation delays human embryo kinetics when oocytes from young and healthy donors are microinjected.
  Esbert MPacheco ASoares SRAmoros DFlorensa MBallesteros AMeseguer M
  Andrology, 6(5):697-706, 2018.

• Very low anti-müllerian hormone concentrations are not an independent predictor of embryo quality and pregnancy rate.
  Pacheco ACruz MIglesias CGarcía-Velasco JA
  Reprod Biomed Online, 37(1):113-119, 2018.

• Impact of vitamin D levels on ovarian reserve and ovarian response to ovarian stimulation in oocyte donors.
  Fabris AMCruz MIglesias CPacheco APatel APatel JFatemi HMGarcía-Velasco JA
  Reprod Biomed Online. 2017 May 19. pii: S1472-6483(17)30235-3. doi: 10.1016/j.rbmo.2017.05.009.

• Sperm DNA fragmentation: from promising to estandarization
  Pacheco AGarcía-Velasco JA
  Transl Androl Urol. 6 (Suppl 4):S341-S342, 2017

• Impact of vitamin D levels on ovarian reserve and ovarian response to ovarian stimulation in oocyte donors.
  Fabris AMCruz MIglesias CPacheco APatel APatel JFatemi HMGarcía-Velasco JA
  Reprod Biomed Online. 2017 May 19. pii: S1472-6483(17)30235-3. doi: 10.1016/j.rbmo.2017.05.009. [Epub ahead of print]

• Impact of very low anti-Müllerian hormone on pregnancy success.
  Pacheco ACruz MGarcía-Velasco JA
  Curr Opin Obstet Gynecol. 2017 Feb 15. doi: 10.1097/GCO.0000000000000354. [Epub ahead of print]

• Sperm DNA integrity: from 'promising' to standardization.
  Pacheco AGarcía-Velasco JA
  Transl Androl Urol. 2017 Sep;6(Suppl 4):S341-S342. doi: 10.21037/tau.2017.08.10. No abstract available.

• Type of gonadotropin during controlled ovarian stimulation affects the endocrine profile in follicular fluid and apoptosis rate in cumulus cells.
  Requena ACruz MAgudo Garcillán D Pacheco AGarcía-Velasco JA
  Eur J Obstet Gynecol Reprod Biol. 2016; 197:142-146

• Type of gonadotropin during controlled ovarian stimulation affects the endocrine profile in follicular fluid and apoptosis rate in cumulus cells
  Requena ACruz MAgudo Garcillán D Pacheco AGarcía-Velasco JA
  Eur J Obstet Gynecol Reprod Biol, 197:142-6, 2016.

• Ongoing pregnancy rates in intrauterine insemination are affected by late follicular-phase progesterone levels.
  Requena ACruz MPacheco AGarcía-Velasco JA
  Fertil Steril 2015; 104:879-883.

• Sperm DNA fragmentation: from promising to estandarization.
  Pacheco A, Garcia-Velasco JA.
  Transl Androl Urol. 6 (Suppl 4):S341-S342, 2017.

• Impact of vitamin D levels on ovarian reserve and ovarian response to ovarian stimulation in oocyte donors.
  Fabris AM, Cruz M, Iglesias C, Pacheco A, Patel A, Patel J, Fatemi H, García-Velasco JA.
  Reprod Biomed Online 35:139-44, 2017.

• Type of gonadotropin during controlled ovarian stimulation affects the endocrine profile in follicular fluid and apoptosis rate in cumulus cells.
  Requena A, Cruz M, Agudo D, Pacheco A, García-Velasco JA.
  Eur J Obstet Gynecol Reprod Biol 197:142-6, 2016.

• Ongoing pregnancy rates in intrauterine insemination are affected by late follicular-phase progesterone levels.
  Requena A, Cruz M, Pacheco A, García-Velasco JA.
  Fertil Steril. 104(4):879-83, 2015.

• Impact of circulating levels of total and bioavailable serum vitamin D on pregnancy rate in egg donation recipients.
  Fabris A, Pacheco A, Cruz M, Puente JM, Fatemi H, Garcia-Velasco JA.
  Fertil Steril. 102:1608-12, 2014.

• The voltage-gated sodium channel nav1.8 is expressed in human sperm.
  Cejudo-Roman A, Pinto FM, Subirán N, Ravina CG, Fernández-Sánchez M, Pérez-Hernández N, Pérez R, Pacheco A, Irazusta J, Candenas L.
  PLoS One. 8:e76084, 2013.

• FSH receptor in vitro modulation by testosterone and hCG in human luteinized granulosa cells.
  García-Velasco JA, Rodriguez S, Agudo D, Pacheco A, Schneider J, Pellicer A.
  Eur J Obst Gynecol Reprod Biol 165: 259-264, 2012.